ScienceDaily

Scientists are uncovering how GLP-1 drugs like Ozempic and Wegovy act on brain regions that control hunger, nausea, pleasure-based eating, and thirst. These discoveries may help create treatments that keep the benefits of weight loss while reducing unwanted side effects.

Researchers have created one of the most detailed virtual mouse cortex simulations ever achieved by combining massive biological datasets with the extraordinary power of Japan’s Fugaku supercomputer. The digital brain behaves like a living system, complete with millions of neurons and tens of billions of synapses, giving scientists the ability to watch diseases like Alzheimer’s or epilepsy unfold…

Researchers have discovered chemical traces of life in rocks older than 3.3 billion years, offering a rare look at Earth’s earliest biology. By combining advanced chemical methods with artificial intelligence, scientists were able to detect faint molecular patterns left behind long after the original biomolecules disappeared. Newly analyzed fossils, including ancient seaweed from Canada’s Yukon T…

Scientists discovered that alcohol activates a sugar-producing pathway in the body, creating fructose that may reinforce addictive drinking. The enzyme responsible, KHK, appears to drive both alcohol cravings and liver injury. When this enzyme was blocked in mice, their drinking decreased and their livers showed far less damage.

Scientists are turning venom, radioisotopes, engineered proteins, and AI into powerful new tools against cancer. From Amazonian scorpions yielding molecules that kill breast cancer cells as effectively as chemotherapy, to improved fibrin sealants and custom-grown bioactive factors, researchers are pushing biotechnology into uncharted territory. Parallel teams are advancing radiotheranostics that …

Cutting-edge simulations show that Enceladus’ plumes are losing 20–40% less mass than earlier estimates suggested. The new models provide sharper insights into subsurface conditions that future landers may one day probe directly.

Rutgers scientists found that metformin can blunt many of the metabolic and cardiovascular improvements normally produced by exercise. Participants who took the drug saw reduced gains in fitness, blood vessel function, and glucose control. The interference may stem from how metformin affects mitochondrial activity.

Chronic kidney disease has surged to nearly 800 million cases and is now among the top causes of death worldwide. The condition is heavily linked to diabetes, hypertension, and obesity, and often goes unnoticed until late stages. Many countries lack access to dialysis and transplants, leaving millions without adequate care.

Scientists have revealed that Hawaiian monk seals produce far more underwater vocalizations than previously believed. Their newly discovered 25-call repertoire includes complex combinations and a rare foraging-related call. These findings highlight an intricate acoustic world unfolding beneath the waves. The research opens the door to better protection strategies as human-made ocean noise continu…

During years of scarce fish, African penguins crowd into the same areas as commercial fishing vessels, heightening competition for dwindling prey. A new metric called “overlap intensity” shows how many penguins are affected and is already shaping improved conservation policies.

Researchers developed a new nano-micelle formulation, CBD-IN, that finally gets CBD into the brain effectively. In mice, it relieved neuropathic pain quickly and didn’t cause the usual movement or memory side effects. Surprisingly, the pain relief didn’t use typical cannabinoid receptors, instead calming abnormal nerve activity more directly. The findings hint at new avenues for treating chronic …

Chronic pain might quietly push people toward developing high blood pressure—and the more widespread the pain, the greater the danger. A massive analysis of over 200,000 adults uncovered strong links between long-lasting pain, depression, inflammation, and rising hypertension risk.

Scientists at Northwestern Medicine have developed a new genetic risk score that predicts who is most likely to experience irregular or dangerous heart rhythms. The test merges several types of genetic analysis into one powerful model, offering doctors a clearer way to spot risk early. Researchers believe this “genetic roadmap” could transform how conditions like AFib are detected and prevented. …

Scientists built a tiny clock from single-electron jumps to probe the true energy cost of quantum timekeeping. They discovered that reading the clock’s output requires vastly more energy than the clock uses to function. This measurement process also drives the irreversibility that defines time’s forward direction. The insight could push researchers to rethink how quantum devices handle informatio…

Scientists used CRISPR to disable the NRF2 gene, restoring chemotherapy sensitivity in lung cancer cells and slowing tumor growth. The technique worked even when only a fraction of tumor cells were edited, making it practical for real-world treatment. Since NRF2 fuels resistance in several cancers, the approach could have broad impact.