ScienceDaily

Vanderbilt researchers created the first selective compound designed to inhibit TAOK-1, a poorly understood protein connected to Alzheimer’s disease. They also discovered a second compound that activates the entire TAOK protein family, offering scientists an unexpected new research tool. Together, the compounds could reveal hidden disease mechanisms and point toward new treatment strategies.

Scientists have identified a molecular switch that may help explain why aging makes the brain more vulnerable to diseases such as ALS and Huntington’s. In worms, the protein EPS8 builds up with age and triggers signaling that encourages toxic proteins to clump together, damaging neurons and shortening lifespan. Reducing EPS8 activity prevented these harmful aggregates and preserved nerve function.

Thawing Arctic permafrost is releasing ancient carbon into the ocean, raising fears that microbes could turn it into greenhouse gases and accelerate climate change. But sediment cores collected near Canada’s Herschel Island reveal a more reassuring twist: most of this land-based carbon becomes buried in the seafloor, while only about 10 percent is converted into gases.

When atomic nuclei smash together at nearly the speed of light, they create the hottest fluid in the universe, but scientists may have overlooked one of its most important forces. New simulations reveal that extreme acceleration builds up along the edges of quark-gluon plasma, helping drive its explosive expansion. This acceleration may do far more than move the fluid, potentially changing its te…

Hidden moon ice may reveal itself through the way it bends and reflects vibrations from moonquakes. The technique could help astronauts locate vital water supplies and uncover clues about the origins of Earth’s oceans.

Low arginine levels may allow cancer cells and viruses to slip past the immune system by reducing production of a crucial cellular warning protein. In mice, arginine-rich diets led to fewer colon tumors and milder viral infections, suggesting a simple supplement could have powerful therapeutic potential.

An AI analysis of 1.2 million satellite images shows that floating algae blooms are spreading across the global ocean. The rapid growth of massive seaweed mats could reshape marine habitats while bringing foul-smelling decay, ecological damage, and economic losses to coastlines.

Coastal communities are facing a hidden threat that is making rising seas far more dangerous: the land beneath them is sinking. New research shows that people in densely populated coastal regions experience an average relative sea-level rise of about 6 millimeters per year, nearly three times the global coastal average. Groundwater pumping, oil and gas extraction, heavy urban development, sedimen…

Researchers have found a way to build much larger “twisted” oxide materials while precisely controlling how their atomic layers line up. Because these materials can be made over large areas and transferred onto different surfaces, the technique could help turn twistronics from a laboratory curiosity into a practical platform for next-generation electronics.

Scientists have figured out how two famously poisonous plants create chemicals with surprising medical potential. After tracking thousands of genes in wolfsbane and larkspur, they identified six enzymes needed to build a complex compound called atisinium. The team recreated the process inside tobacco plants, offering a sustainable way to produce and test these rare molecules in larger amounts.

The solar wind may be stripping away Mars’ atmosphere by creating giant rolling waves along its outer edge. Data from MAVEN and Tianwen-1 show that these waves form plasma clouds that carry atmospheric particles into space. The process is concentrated on one side of Mars and may have played a major role in drying out the once potentially habitable planet.

Global warming appears to have shifted into a faster gear. After removing the effects of El Niño, volcanic eruptions, and solar cycles, researchers found that the planet has warmed at roughly 0.35°C per decade over the past ten years, compared with just under 0.2°C per decade from 1970 to 2015. The acceleration, which becomes visible around 2013 to 2015, appeared across five major global temperat…

A surprisingly small dose of exercise may deliver major health benefits for adults carrying excess fat around the waist. In a four-month trial involving 315 adults with central obesity, researchers found that completing 75 minutes of brisk interval walking in a single weekly session reduced body fat, trimmed waistlines, and improved cardiovascular fitness about as effectively as splitting the sam…

Dark matter particles may exert a hidden force on one another, but its effects are stranger than expected. An extra attraction helps the particles cluster, yet it also makes dark matter effectively lighter as the Universe expands. That weakens its gravitational impact and usually slows the growth of cosmic structure rather than accelerating it.

A protein once thought to mainly protect chromosome ends may also be essential for keeping muscle stem cells ready to repair injuries. Researchers found that TRF2 helps these cells maintain their identity and coordinate the cycle of rest, repair, and renewal.