ScienceDaily

Tirzepatide, sold as Mounjaro and Zepbound, activated calorie-burning brown fat in obese mice, revealing a potential metabolic effect beyond appetite suppression. If confirmed in humans, the finding could help explain the drug’s powerful benefits and inspire more comprehensive treatments for obesity and diabetes.

Scientists discovered a surprising energy paradox in the brain during REM sleep, the stage most closely associated with dreaming. Blood supply to the brain begins increasing even before REM starts, but neurons’ immediately available energy, measured as ATP, then drops. The finding suggests that dreaming may require such intense internal processing that neurons consume energy faster than it can be…

Scientists have found that a famous 2-billion-year-old chemical signature, once thought to record a massive global change in Earth’s carbon cycle, may instead have been produced by local magma, hydrocarbons, and methane-eating microbes. The discovery raises new questions about what was really happening as oxygen transformed the young planet.

Researchers found that scented cleaners can react with ozone indoors to create billions or trillions of invisible nanoparticles that can penetrate deep into the lungs. The pollution forms within minutes and, in some cases, may produce an inhaled particle dose comparable to or greater than standing near heavy traffic.

Artemis II astronauts Victor Glover and Reid Wiseman are transitioning to emeritus status at NASA after their historic journey around the Moon earlier this year. The pair will continue advising and mentoring NASA teams as preparations accelerate for Artemis III and future lunar missions. Their experience with Orion and deep-space operations could prove especially valuable as NASA works toward ret…

Scientists recreated a particle-forming process linked to the extreme physics of the early universe using a 13-ion quantum simulator. The breakthrough suggests quantum computers could eventually help researchers investigate how matter formed and evolved after the Big Bang.

Scientists discovered that tiny amounts of lead in ancient ink can make writing inside burned papyrus scrolls stand out dramatically in X-ray scans. The technique could help unlock lost Greek and Roman texts preserved by the eruption of Mount Vesuvius nearly 2,000 years ago.

Scientists discovered two strange new sea spider species in the Salish Sea, including a hairy-legged, red-eyed species that can groom itself with comb-like appendages. Another is frequently covered in tiny parasites, and researchers say many more undiscovered sea spiders may still be hiding in the region.

Scientists discovered rare flavoalkaloids in Cannabis leaves for the first time, along with dozens of other phenolic compounds that had never been reported in the plant. The findings suggest that Cannabis leaves, often discarded as waste, may contain a surprisingly rich source of potentially useful chemicals.

Scientists think beneficial fungi could help transform nutrient-poor lunar and Martian regolith into a material capable of supporting crops. By helping plants access nutrients and withstand harsh conditions, these microbes could someday make self-sustaining space farming more realistic.

A new analysis suggests mammograms may lead to far less breast cancer overdiagnosis than some earlier studies indicated. Researchers reexamined all eight major randomized screening trials and accounted for differences in follow-up time, screening frequency, and screening after trials ended. Their results were consistent with an overdiagnosis rate below 5%, rather than estimates approaching 30% to…

CERN has started replacing some of the Large Hadron Collider’s most important magnets as part of its High-Luminosity upgrade. The new superconducting magnets will produce fields about 40% stronger, allowing particle beams to be squeezed more tightly before they collide. That should create far more collisions for the ATLAS and CMS experiments to analyze, giving physicists a much larger window into…

Scientists have captured a subduction zone off Vancouver Island in the process of tearing itself apart, revealing that these massive tectonic systems may die piece by piece rather than all at once. The discovery could help explain ancient plate fragments, volcanic activity, and how hidden breaks beneath Cascadia may influence future earthquakes.

Researchers used CRISPR to remove CD33 from donor stem cells, potentially giving doctors a way to attack aggressive blood cancers without destroying the healthy cells patients need after a transplant. In a 30-patient trial, the edited cells successfully took hold and appeared to shield blood cells from a CD33-targeted cancer treatment.

A major analysis suggests Phelan-McDermid syndrome, a genetic disorder closely linked to autism, may affect about 1 in 7,300 people and more than 45,000 Americans. Researchers warn that thousands of cases may remain hidden because genetic testing is often not performed, even as targeted treatments move into clinical trials.