ScienceDaily

A large health-record analysis found that glucosamine use was associated with a 25% higher likelihood of mild cognitive impairment progressing to dementia. Lab experiments suggest the popular joint supplement may intensify an abnormal sugar-tagging process in the Alzheimer’s brain, although researchers say clinical trials are needed to determine whether it actually causes harm.

Pain and fatigue in rheumatoid arthritis can persist even after inflammation improves, with depression, poor sleep, obesity, smoking, and chronic pain potentially helping sustain symptoms. Researchers say identifying these hidden drivers could prevent unnecessary medication changes and lead to more personalized treatment.

Scientists studying ancient Australian rocks uncovered more than 12,000 fossils from some of the oldest known eukaryotes on Earth. These early complex cells lived in settings ranging from coastal mudflats to the open sea, but only where oxygen was available. Oxygen-free environments contained simpler microbes instead. The findings strengthen the idea that oxygen played a crucial role in the emerg…

Ancient DNA shows that adults and children buried together in medieval Sweden were often not members of the same immediate family, suggesting that burial choices reflected more than biological kinship. The research also revealed early gender-based burial customs and uncovered the remarkable story of a young woman who may have completed a pilgrimage across Europe.

Scientists have streamlined a method for measuring DNA-bound phosphorus in soil, making it cheaper and easier while preserving its accuracy. The technique could reveal how soil microbes help recycle phosphorus and ultimately support more sustainable fertilizer and nutrient management.

Direct oral anticoagulants cut the risk of serious clinical events by 69% in atrial fibrillation patients with an intermediate risk of stroke, according to the randomized SINGLE-AF trial. The benefit was driven mainly by fewer ischemic strokes, with no increase in major bleeding.

A single dose of an experimental CRISPR therapy cut LDL cholesterol and triglycerides by about half in patients with difficult-to-treat lipid disorders. The reductions were still present one year later, with the highest dose lowering LDL by 52.5% and triglycerides by 47.8%.

Scientists have mapped the genetics of cat cancer on an unprecedented scale and found surprising similarities with tumors in humans. The findings could help bring precision cancer treatments to cats while also revealing new clues about how human cancers develop and respond to drugs.

Tirzepatide, sold as Mounjaro and Zepbound, activated calorie-burning brown fat in obese mice, revealing a potential metabolic effect beyond appetite suppression. If confirmed in humans, the finding could help explain the drug’s powerful benefits and inspire more comprehensive treatments for obesity and diabetes.

Scientists discovered a surprising energy paradox in the brain during REM sleep, the stage most closely associated with dreaming. Blood supply to the brain begins increasing even before REM starts, but neurons’ immediately available energy, measured as ATP, then drops. The finding suggests that dreaming may require such intense internal processing that neurons consume energy faster than it can be…

Scientists have found that a famous 2-billion-year-old chemical signature, once thought to record a massive global change in Earth’s carbon cycle, may instead have been produced by local magma, hydrocarbons, and methane-eating microbes. The discovery raises new questions about what was really happening as oxygen transformed the young planet.

Researchers found that scented cleaners can react with ozone indoors to create billions or trillions of invisible nanoparticles that can penetrate deep into the lungs. The pollution forms within minutes and, in some cases, may produce an inhaled particle dose comparable to or greater than standing near heavy traffic.

Artemis II astronauts Victor Glover and Reid Wiseman are transitioning to emeritus status at NASA after their historic journey around the Moon earlier this year. The pair will continue advising and mentoring NASA teams as preparations accelerate for Artemis III and future lunar missions. Their experience with Orion and deep-space operations could prove especially valuable as NASA works toward ret…

Scientists recreated a particle-forming process linked to the extreme physics of the early universe using a 13-ion quantum simulator. The breakthrough suggests quantum computers could eventually help researchers investigate how matter formed and evolved after the Big Bang.

Scientists discovered that tiny amounts of lead in ancient ink can make writing inside burned papyrus scrolls stand out dramatically in X-ray scans. The technique could help unlock lost Greek and Roman texts preserved by the eruption of Mount Vesuvius nearly 2,000 years ago.